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Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining
DNA polymerase θ (Polθ) promotes insertion mutations during alternative end-joining (alt-EJ) by an unknown mechanism. Here, we discover that mammalian Polθ transfers nucleotides to the 3’ terminus of DNA during alt-EJ in vitro and in vivo by oscillating between three different modes of terminal tran...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912351/ https://ncbi.nlm.nih.gov/pubmed/27311885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13740 |
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