Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide

Epigenome regulates gene expression to determine cell fate, and accumulation of epigenomic aberrations leads to diseases, including cancer. NCD38 inhibits lysine-specific demethylase-1 (LSD1), a histone demethylase targeting H3K4me1 and H3K4me2, but not H3K4me3. In this study, we conjugated NCD38 wi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Alagarswamy, Kokiladevi, Shinohara, Ken-Ichi, Takayanagi, Shihori, Fukuyo, Masaki, Okabe, Atsushi, Rahmutulla, Bahityar, Yoda, Natsumi, Qin, Rui, Shiga, Naoki, Sugiura, Masahiro, Sato, Hiroaki, Kita, Kazuko, Suzuki, Takayoshi, Nemoto, Tetsuhiro, Kaneda, Atsushi
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047668/
https://ncbi.nlm.nih.gov/pubmed/30034620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25451
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky