Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide

Epigenome regulates gene expression to determine cell fate, and accumulation of epigenomic aberrations leads to diseases, including cancer. NCD38 inhibits lysine-specific demethylase-1 (LSD1), a histone demethylase targeting H3K4me1 and H3K4me2, but not H3K4me3. In this study, we conjugated NCD38 wi...

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Publicado en:Oncotarget
Autores principales: Alagarswamy, Kokiladevi, Shinohara, Ken-Ichi, Takayanagi, Shihori, Fukuyo, Masaki, Okabe, Atsushi, Rahmutulla, Bahityar, Yoda, Natsumi, Qin, Rui, Shiga, Naoki, Sugiura, Masahiro, Sato, Hiroaki, Kita, Kazuko, Suzuki, Takayoshi, Nemoto, Tetsuhiro, Kaneda, Atsushi
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047668/
https://ncbi.nlm.nih.gov/pubmed/30034620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25451
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