The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats

We investigated the effect of aging on hepatic pharmacokinetics and the degree of hepatotoxicity following a toxic dose of acetaminophen. Young and old male Fischer 344 rats were treated with 800 mg/kg acetaminophen (young n = 8, old n = 5) or saline (young n = 9, old n = 9). Serum measurements show...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Gerontol A Biol Sci Med Sci
मुख्य लेखकों: Mach, John, Huizer-Pajkos, Aniko, Cogger, Victoria C, McKenzie, Catriona, Le Couteur, David G, Jones, Brett E, de Cabo, Rafael, Hilmer, Sarah N
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2014
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047318/
https://ncbi.nlm.nih.gov/pubmed/23863315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt095
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