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The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats
Isoniazid is the first-line treatment for tuberculosis; however, its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain. We aimed to investigate these in young (3 ± 0 months, n = 26) and old (23.0 ± 0.2 months, n = 27) male Fische...
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| Publicado no: | Fundam Clin Pharmacol |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5976487/ https://ncbi.nlm.nih.gov/pubmed/26454000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/fcp.12157 |
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