Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

Dynamic protein interaction networks such as DNA double-strand break (DSB) signaling are modulated by post-translational modifications (PTMs). The DNA repair factor 53BP1 is a rare example of a protein whose PTM binding function can be switched on and off. 53BP1 is recruited to DSBs by recognizing h...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Botuyan, Maria Victoria, Cui, Gaofeng, Drané, Pascal, Oliveira, Catarina, Detappe, Alexandre, Brault, Marie Eve, Parnandi, Nishita, Chaubey, Shweta, Thompson, James R., Bragantini, Benoît, Zhao, Debiao, Chapman, J. Ross, Chowdhury, Dipanjan, Mer, Georges
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045459/
https://ncbi.nlm.nih.gov/pubmed/29967538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0083-z
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