TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

53BP1 is a multi-functional double-strand break (DSB) repair protein that is essential for class switch recombination in B lymphocytes and for sensitizing BRCA1-deficient tumors to PARP inhibitors. Central to all 53BP1 activities is its recruitment to DSBs via the interaction of the tandem Tudor dom...

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Gepubliceerd in:Nature
Hoofdauteurs: Drané, Pascal, Brault, Marie-Eve, Cui, Gaofeng, Meghani, Khyati, Chaubey, Shweta, Detappe, Alexandre, Parnandi, Nishita, He, Yizhou, Zheng, Xiao-Feng, Botuyan, Maria Victoria, Kalousi, Alkmini, Yewdell, William T, Münch, Christian, Harper, J Wade, Chaudhuri, Jayanta, Soutoglou, Evi, Mer, Georges, Chowdhury, Dipanjan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441565/
https://ncbi.nlm.nih.gov/pubmed/28241136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21358
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