Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs

DNA lesions are sensed by a network of proteins that trigger the DNA damage response (DDR), a signaling cascade that acts to delay cell cycle progression and initiate DNA repair. The Mediator of DNA damage Checkpoint protein 1 (MDC1) is essential for spreading of the DDR signaling on chromatin surro...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Nagy, Zita, Kalousi, Alkmini, Furst, Audrey, Koch, Marc, Fischer, Benoit, Soutoglou, Evi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741384/
https://ncbi.nlm.nih.gov/pubmed/26845027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005791
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