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DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome integrity. The readout of DSB repair may depend on whether DSBs occur at transcribed versus non-transcribed regions. Some studies have postulated that DNA-RNA hybrids form at DS...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ortega, Pedro, Mérida-Cerro, José Antonio, Rondón, Ana G, Gómez-González, Belén, Aguilera, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289408/
https://ncbi.nlm.nih.gov/pubmed/34236317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.69881
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