Systemic Depletion of Nerve Growth Factor Inhibits Disease Progression in a Genetically Engineered Model of Pancreatic Ductal Adenocarcinoma

OBJECTIVES: In pancreatic ductal adenocarcinoma (PDAC) patients, increased expression of proinflammatory neurotrophic growth factors (e.g. nerve growth factor (NGF)) correlates with a poorer prognosis, perineural invasion (PNI) and, with regard to NGF, pain severity. We hypothesized that NGF sequest...

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Gepubliceerd in:Pancreas
Hoofdauteurs: Saloman, Jami L., Singhi, Aatur D., Hartman, Douglas J., Normolle, Daniel P., Albers, Kathryn M., Davis, Brian M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044729/
https://ncbi.nlm.nih.gov/pubmed/29975347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000001090
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