Differential effects of depleting versus programming tumor-associated macrophages on engineered T cells in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapies, including immune checkpoint blockade. We investigated two distinct strategies to modulate tumor-associated macrophages (TAMs) to enhance cellular therapy targeting mesothelin in an autochthonous PDA mouse model. Ad...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Stromnes, Ingunn M., Burrack, Adam L., Hulbert, Ayaka, Bonson, Patrick, Black, Cheryl, Brockenbrough, J. Scott, Raynor, Jackson F., Spartz, Ellen J., Pierce, Robert H., Greenberg, Philip D., Hingorani, Sunil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548612/
https://ncbi.nlm.nih.gov/pubmed/31028033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0448
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