T cells engineered against a native antigen can surmount immunologic and physical barriers to treat pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinomas (PDA) erect physical barriers to chemotherapy and induce multiple mechanisms of immune suppression, creating a sanctuary for unimpeded growth. We tested the ability of T cells engineered to express an affinity-enhanced T cell receptor (TCR) against a native antigen...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Cell
Hlavní autoři: Stromnes, Ingunn M., Schmitt, Thomas M., Hulbert, Ayaka, Brockenbrough, J. Scott, Nguyen, Hieu, Cuevas, Carlos, Dotson, Ashley M., Tan, Xiaoxia, Hotes, Jennifer L., Greenberg, Philip D., Hingorani, Sunil R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724422/
https://ncbi.nlm.nih.gov/pubmed/26525103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.09.022
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky