T cells engineered against a native antigen can surmount immunologic and physical barriers to treat pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinomas (PDA) erect physical barriers to chemotherapy and induce multiple mechanisms of immune suppression, creating a sanctuary for unimpeded growth. We tested the ability of T cells engineered to express an affinity-enhanced T cell receptor (TCR) against a native antigen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Cell
Prif Awduron: Stromnes, Ingunn M., Schmitt, Thomas M., Hulbert, Ayaka, Brockenbrough, J. Scott, Nguyen, Hieu, Cuevas, Carlos, Dotson, Ashley M., Tan, Xiaoxia, Hotes, Jennifer L., Greenberg, Philip D., Hingorani, Sunil R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724422/
https://ncbi.nlm.nih.gov/pubmed/26525103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.09.022
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