Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an exuberant inflammatory desmoplastic response. The PDAC microenvironment is complex, containing both pro- and antitumorigenic elements, and remains to be fully characterized. Here, we show that sensory neurons, an under-studied cohort of...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Saloman, Jami L., Albers, Kathryn M., Li, Dongjun, Hartman, Douglas J., Crawford, Howard C., Muha, Emily A., Rhim, Andrew D., Davis, Brian M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801275/
https://ncbi.nlm.nih.gov/pubmed/26929329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512603113
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