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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinomas (PDA) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates inordinately high interstitial fluid pressures (IFP), exceeding those previously measured or theorized for solid tumors, and induces vascular colla...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371414/ https://ncbi.nlm.nih.gov/pubmed/22439937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.01.007 |
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