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Epidermal growth factor receptor inhibition with Gefitinib does not alter lung responses to mechanical ventilation in fetal, preterm lambs

BACKGROUND: Epidermal growth factor receptor (EGFR) is important for airway branching and lung maturation. Mechanical ventilation of preterm lambs causes increases in EGFR and EGFR ligand mRNA in the lung. Abnormal EGFR signaling may contribute to the development of bronchopulmonary dysplasia. HYPOT...

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發表在:PLoS One
Main Authors: Kothe, T. Brett, Royse, Emily, Kemp, Matthew W., Usuda, Haruo, Saito, Masatoshi, Musk, Gabrielle C., Jobe, Alan H., Hillman, Noah H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044532/
https://ncbi.nlm.nih.gov/pubmed/30005089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200713
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