Epidermal growth factor receptor inhibition with Gefitinib does not alter lung responses to mechanical ventilation in fetal, preterm lambs

BACKGROUND: Epidermal growth factor receptor (EGFR) is important for airway branching and lung maturation. Mechanical ventilation of preterm lambs causes increases in EGFR and EGFR ligand mRNA in the lung. Abnormal EGFR signaling may contribute to the development of bronchopulmonary dysplasia. HYPOT...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kothe, T. Brett, Royse, Emily, Kemp, Matthew W., Usuda, Haruo, Saito, Masatoshi, Musk, Gabrielle C., Jobe, Alan H., Hillman, Noah H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044532/
https://ncbi.nlm.nih.gov/pubmed/30005089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200713
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