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Epidermal growth factor receptor inhibition with Gefitinib does not alter lung responses to mechanical ventilation in fetal, preterm lambs

BACKGROUND: Epidermal growth factor receptor (EGFR) is important for airway branching and lung maturation. Mechanical ventilation of preterm lambs causes increases in EGFR and EGFR ligand mRNA in the lung. Abnormal EGFR signaling may contribute to the development of bronchopulmonary dysplasia. HYPOT...

詳細記述

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書誌詳細
出版年:PLoS One
主要な著者: Kothe, T. Brett, Royse, Emily, Kemp, Matthew W., Usuda, Haruo, Saito, Masatoshi, Musk, Gabrielle C., Jobe, Alan H., Hillman, Noah H.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044532/
https://ncbi.nlm.nih.gov/pubmed/30005089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200713
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