Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria

Protein overload of proximal tubular cells (PTCs) can promote interstitial injury by unclear mechanisms that may involve activation of innate immunity. We investigated whether prolonged exposure of tubular cells to high protein concentrations stimulates innate immunity, triggering progressive inters...

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Dettagli Bibliografici
Pubblicato in:Biosci Rep
Autori principali: Faustino, Viviane Dias, Arias, Simone Costa Alarcon, Ferreira Ávila, Victor, Foresto-Neto, Orestes, Zambom, Fernanda Florencia Fregnan, Machado, Flavia Gomes, Machado dos Reis, Luciene, Malheiros, Denise Maria Avancini Costa, Volpini, Rildo Aparecido, Camara, Niels Olsen Saraiva, Zatz, Roberto, Fujihara, Clarice Kazue
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043717/
https://ncbi.nlm.nih.gov/pubmed/29914975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180762
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