NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Foresto-Neto, Orestes, Albino, Amanda Helen, Arias, Simone Costa Alarcon, Faustino, Viviane Dias, Zambom, Fernanda Florencia Fregnan, Cenedeze, Marcos Antonio, Elias, Rosilene Motta, Malheiros, Denise Maria Avancini Costa, Camara, Niels Olsen Saraiva, Fujihara, Clarice Kazue, Zatz, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026681/
https://ncbi.nlm.nih.gov/pubmed/32116790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00084
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