NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM...

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Bibliografiska uppgifter
I publikationen:Front Physiol
Huvudupphovsmän: Foresto-Neto, Orestes, Albino, Amanda Helen, Arias, Simone Costa Alarcon, Faustino, Viviane Dias, Zambom, Fernanda Florencia Fregnan, Cenedeze, Marcos Antonio, Elias, Rosilene Motta, Malheiros, Denise Maria Avancini Costa, Camara, Niels Olsen Saraiva, Fujihara, Clarice Kazue, Zatz, Roberto
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Physiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026681/
https://ncbi.nlm.nih.gov/pubmed/32116790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00084
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