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Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
53BP1 performs essential functions in DNA double-strand break (DSB) repair and it was recently reported that Tudor interacting repair regulator (TIRR) negatively regulates 53BP1 during DSB repair. Here, we present the crystal structure of the 53BP1 tandem Tudor domain (TTD) in complex with TIRR. Our...
שמור ב:
| הוצא לאור ב: | Nat Commun |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6043480/ https://ncbi.nlm.nih.gov/pubmed/30002377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05174-9 |
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