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Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: A novel mechanism linking STAT3/Rab proteins

Hypoxia-mediated tumor progression, metastasis, and drug resistance are major clinical challenges in ovarian cancer. Exosomes released in the hypoxic tumor microenvironment may contribute to these challenges by transferring signaling proteins between cancer cells and normal cells. We observed that o...

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Dettagli Bibliografici
Pubblicato in:Oncogene
Autori principali: Dorayappan, Kalpana Deepa Priya, Wanner, Ross, Wallbillich, John J., Saini, Uksha, Zingarelli, Roman, Suarez, Adrian A., Cohn, David E., Selvendiran, Karuppaiyah
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043362/
https://ncbi.nlm.nih.gov/pubmed/29636548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0189-0
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