High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer

OBJECTIVES: STAT3 is over-expressed in endometrial cancer, and diabetes is a risk factor for the development of type 1 endometrial cancer. We therefore investigated whether glucose concentrations influence STAT3 expression in type 1 endometrial cancer, and whether such STAT3 expression might be inhi...

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Pubblicato in:PLoS One
Autori principali: Wallbillich, John J., Josyula, Srirama, Saini, Uksha, Zingarelli, Roman A., Dorayappan, Kalpana Deepa Priya, Riley, Maria K., Wanner, Ross A., Cohn, David E., Selvendiran, Karuppaiyah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256996/
https://ncbi.nlm.nih.gov/pubmed/28114390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170318
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