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Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: A novel mechanism linking STAT3/Rab proteins

Hypoxia-mediated tumor progression, metastasis, and drug resistance are major clinical challenges in ovarian cancer. Exosomes released in the hypoxic tumor microenvironment may contribute to these challenges by transferring signaling proteins between cancer cells and normal cells. We observed that o...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Dorayappan, Kalpana Deepa Priya, Wanner, Ross, Wallbillich, John J., Saini, Uksha, Zingarelli, Roman, Suarez, Adrian A., Cohn, David E., Selvendiran, Karuppaiyah
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043362/
https://ncbi.nlm.nih.gov/pubmed/29636548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0189-0
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