Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells

Current anti-cancer strategy takes advantage of tumour specific abnormalities in DNA damage response to radio- or chemo-therapy. Inhibition of the ATR/Chk1 pathway has been shown to be synthetically lethal in cells with high levels of oncogene-induced replication stress and in p53- or ATM- deficient...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Šalovská, Barbora, Janečková, Hana, Fabrik, Ivo, Karlíková, Radana, Čecháková, Lucie, Ondrej, Martin, Link, Marek, Friedecký, David, Tichý, Aleš
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042708/
https://ncbi.nlm.nih.gov/pubmed/30001349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199349
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