DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

BACKGROUND: DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for modifying cytosine to 5-methylcytosine (5mC), which can be further oxidized by the TET dioxygenases to ultimately cause D...

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Bibliographische Detailangaben
Veröffentlicht in:Genome Biol
Hauptverfasser: Gu, Tianpeng, Lin, Xueqiu, Cullen, Sean M., Luo, Min, Jeong, Mira, Estecio, Marcos, Shen, Jianjun, Hardikar, Swanand, Sun, Deqiang, Su, Jianzhong, Rux, Danielle, Guzman, Anna, Lee, Minjung, Qi, Lei Stanley, Chen, Jia-Jia, Kyba, Michael, Huang, Yun, Chen, Taiping, Li, Wei, Goodell, Margaret A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042404/
https://ncbi.nlm.nih.gov/pubmed/30001199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1464-7
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