STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer

BACKGROUND: Serine/threonine protein kinase 25 (STK25) is critical in regulating whole-body glucose and insulin homeostasis and the accumulation of ectopic lipids. The Warburg effect, also known as aerobic glycolysis, is an essential metabolic characteristic of cancer cells. However, the effects of...

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Опубликовано в: :J Exp Clin Cancer Res
Главные авторы: Wu, Fan, Gao, Pin, Wu, Wei, Wang, Zaozao, Yang, Jie, Di, Jiabo, Jiang, Beihai, Su, Xiangqian
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042396/
https://ncbi.nlm.nih.gov/pubmed/29996891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0808-1
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