A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus

Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking, or direct selection on the physicochemical cost of high fidelity. However, for many systems, it has been difficult to disentangle the relative impact of these forces empirically. In RNA viruses, an observ...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Fitzsimmons, William J., Woods, Robert J., McCrone, John T., Woodman, Andrew, Arnold, Jamie J., Yennawar, Madhumita, Evans, Richard, Cameron, Craig E., Lauring, Adam S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040757/
https://ncbi.nlm.nih.gov/pubmed/29953453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006459
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