A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus

Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking, or direct selection on the physicochemical cost of high fidelity. However, for many systems, it has been difficult to disentangle the relative impact of these forces empirically. In RNA viruses, an observ...

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Detalles Bibliográficos
Publicado en:PLoS Biol
Autores principales: Fitzsimmons, William J., Woods, Robert J., McCrone, John T., Woodman, Andrew, Arnold, Jamie J., Yennawar, Madhumita, Evans, Richard, Cameron, Craig E., Lauring, Adam S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040757/
https://ncbi.nlm.nih.gov/pubmed/29953453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006459
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