Regulation of δ Opioid Receptor-Mediated Signaling and Antinociception in Peripheral Sensory Neurons by Arachidonic Acid–Dependent 12/15-Lipoxygenase Metabolites

The function of δ opioid receptors (DOR) expressed by peripheral pain-sensing neurons (nociceptors) is regulated by both cyclooxygenase- and lipoxygenase (LOX)-dependent arachidonic acid (AA) metabolites. Whereas cyclooxygenase metabolites enhance responsiveness, LOX metabolites elicit a refractory,...

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Sullivan, Laura C., Chavera, Teresa A., Gao, Xiaoli, Pando, Miryam M., Berg, Kelly A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
Matèries:
Cellular and Molecular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040089/
https://ncbi.nlm.nih.gov/pubmed/28465374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.241604
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