Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α–Dependent Manner

17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain unknown. We hypothesized that the protective effect...

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Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Frump, Andrea L., Selej, Mona, Wood, Jordan A., Albrecht, Marjorie, Yakubov, Bakhtiyor, Petrache, Irina, Lahm, Tim
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039879/
https://ncbi.nlm.nih.gov/pubmed/29394091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0167OC
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