Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure

The development of pulmonary hypertension (PH) requires multiple pulmonary vascular insults, yet the role of early oxygen therapy as an initial pulmonary vascular insult remains poorly defined. Here, we employ a two-hit model of PH, utilizing postnatal hyperoxia followed by adult hypoxia exposure, t...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Goss, Kara N., Cucci, Anthony R., Fisher, Amanda J., Albrecht, Marjorie, Frump, Andrea, Tursunova, Roziya, Gao, Yong, Brown, Mary Beth, Petrache, Irina, Tepper, Robert S., Ahlfeld, Shawn K., Lahm, Tim
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398870/
https://ncbi.nlm.nih.gov/pubmed/25659904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00276.2014
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