Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Activation of microglia by classical inflammatory mediators can convert astrocytes to a neurotoxic A1 phenotype in a variety of neurological diseases(1,2). Development of agents that could inhibit the formation of A1 reactive astrocytes could be used to treat these diseases for which there are no di...

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Publicado no:Nat Med
Main Authors: Yun, Seung Pil, Kam, Tae-In, Panicker, Nikhil, Kim, SangMin, Oh, Yumin, Park, Jong-Sung, Kwon, Seung-Hwan, Park, Yong Joo, Karuppagounder, Senthilkumar S., Park, Hyejin, Kim, Sangjune, Oh, Nayeon, Kim, Nayoung Alice, Lee, Saebom, Brahmachari, Saurav, Mao, Xiaobo, Lee, Jun Hee, Kumar, Manoj, An, Daniel, Kang, Sung-Ung, Lee, Yunjong, Lee, Kang Choon, Na, Dong Hee, Kim, Donghoon, Lee, Sang Hun, Roschke, Viktor V., Liddelow, Shane A., Mari, Zoltan, Barres, Ben. A., Dawson, Valina L., Lee, Seulki, Dawson, Ted M., Ko, Han Seok
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039259/
https://ncbi.nlm.nih.gov/pubmed/29892066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0051-5
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