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Traversing Steric Limitations via Cooperative Lewis Base/Pd Catalysis: An Enantioselective Synthesis of α-Branched Esters using 2-Substituted Electrophiles

Cooperative catalysis enables the direct enantioselective α-allylation of linear prochiral esters using 2-substituted allyl electrophiles. Critical to the successful development of the method was the recognition that metal-centered reactivity and the source of enantiocontrol are independent. This fe...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Schwarz, Kevin J., Pearson, Colin M., Cintron-Rosado, Gabriel A., Liu, Peng, Snaddon, Thomas N.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038818/
https://ncbi.nlm.nih.gov/pubmed/29701289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803277
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