Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

BACKGROUND: Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade. METHODS: We examined the molecular and functional effects of single and...

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Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Del Curatolo, Anais, Conciatori, Fabiana, Cesta Incani, Ursula, Bazzichetto, Chiara, Falcone, Italia, Corbo, Vincenzo, D’Agosto, Sabrina, Eramo, Adriana, Sette, Giovanni, Sperduti, Isabella, De Luca, Teresa, Marabese, Mirko, Shirasawa, Senji, De Maria, Ruggero, Scarpa, Aldo, Broggini, Massimo, Del Bufalo, Donatella, Cognetti, Francesco, Milella, Michele, Ciuffreda, Ludovica
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038340/
https://ncbi.nlm.nih.gov/pubmed/29986755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0820-5
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