Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

BACKGROUND: Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade. METHODS: We examined the molecular and functional effects of single and...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Del Curatolo, Anais, Conciatori, Fabiana, Cesta Incani, Ursula, Bazzichetto, Chiara, Falcone, Italia, Corbo, Vincenzo, D’Agosto, Sabrina, Eramo, Adriana, Sette, Giovanni, Sperduti, Isabella, De Luca, Teresa, Marabese, Mirko, Shirasawa, Senji, De Maria, Ruggero, Scarpa, Aldo, Broggini, Massimo, Del Bufalo, Donatella, Cognetti, Francesco, Milella, Michele, Ciuffreda, Ludovica
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038340/
https://ncbi.nlm.nih.gov/pubmed/29986755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0820-5
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