mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis

A pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter accompanied by compromised remyelination. Demyelinated lesions are deeply associated with oligodendrocyte apoptosis and a robust inflammatory response. Although various studies point towards a noxious role of inf...

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Dettagli Bibliografici
Pubblicato in:Front Cell Neurosci
Autori principali: Laflamme, Nathalie, Cisbani, Giulia, Préfontaine, Paul, Srour, Younes, Bernier, Jordan, St-Pierre, Marie-Kim, Tremblay, Marie-Ève, Rivest, Serge
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037698/
https://ncbi.nlm.nih.gov/pubmed/30018535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00178
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