Immune-Active Microenvironment in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Rationale for Immune Checkpoint Blockade

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a highly aggressive monogenic cancer driven by SMARCA4 mutations. Here, we report responses to anti-PD1 immunotherapy in four patients and characterize the immune landscape of SCCOHT tumors using quantitative immunofluorescence and g...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Jelinic, Petar, Ricca, Jacob, Van Oudenhove, Elke, Olvera, Narciso, Merghoub, Taha, Levine, Douglas A, Zamarin, Dmitriy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037122/
https://ncbi.nlm.nih.gov/pubmed/29365144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djx277
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