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Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice
In mice, fetal/neonatal B-1 cell development generates murine CD5(+) B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a V(H)11/D/J(H) knock-in mouse line (V(H)11t) that generates an autoreactive antiphosphatidylcholine BCR. Our study revealed that antiphosphatidylcho...
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| 發表在: | J Immunol |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
AAI
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6036230/ https://ncbi.nlm.nih.gov/pubmed/29898964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800400 |
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