Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

Therapeutic cancer vaccines require adjuvants leading to robust type I interferon and proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor response. Cyclic dinucleotides (CDNs), a potent Stimulator of Interferon Receptor (STING) agonist, are currently in phase I t...

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Udgivet i:Nanomedicine
Main Authors: Wilson, David R., Sen, Rupashree, Sunshine, Joel C., Pardoll, Drew M., Green, Jordan J., Kim, Young J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035751/
https://ncbi.nlm.nih.gov/pubmed/29127039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2017.10.013
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