A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma

Cellular components of solid tumors including DNA are released into the bloodstream, but data on circulating-free DNA (cfDNA) in hepatocellular carcinoma (HCC) are still scarce. This study aimed at analyzing mutations in cfDNA and their correlation with tissue mutations in patients with HCC. We incl...

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Veröffentlicht in:Oncogene
Hauptverfasser: Labgaa, Ismail, Villacorta-Martin, Carlos, D’Avola, Delia, Craig, Amanda, von Felden, Johann, Martins-Filho, Sebastiao N., Sia, Daniela, Stueck, Ashley, Ward, Stephen C., Fiel, M. Isabel, Mahajan, Milind, Tabrizian, Parissa, Thung, Swan N., Ang, Celina, Friedman, Scott L., Llovet, Josep M., Schwartz, Myron, Villanueva, Augusto
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035113/
https://ncbi.nlm.nih.gov/pubmed/29628508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0206-3
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