Cancer Immunotherapy with Recombinant Poliovirus Induces IFN-Dominant Activation of Dendritic Cells and Tumor Antigen-Specific CTLs

Tumors thrive in an immunosuppressive microenvironment that impedes antitumor innate and adaptive immune responses. Thus, approaches that can overcome immunosuppression and engage antitumor immunity are needed. This study defines the adjuvant and cancer immunotherapy potential of the recombinant pol...

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Pubblicato in:Sci Transl Med
Autori principali: Brown, Michael C., Holl, Eda K., Boczkowski, David, Dobrikova, Elena, Mosaheb, Mubeen, Chandramohan, Vidya, Bigner, Darell D., Gromeier, Matthias, Nair, Smita K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034685/
https://ncbi.nlm.nih.gov/pubmed/28931654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan4220
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