The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK agonist AICAR suppresses IFNγ...

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Publicado en:EMBO Mol Med
Autores principales: Hall, Derek T, Griss, Takla, Ma, Jennifer F, Sanchez, Brenda Janice, Sadek, Jason, Tremblay, Anne Marie K, Mubaid, Souad, Omer, Amr, Ford, Rebecca J, Bedard, Nathalie, Pause, Arnim, Wing, Simon S, Di Marco, Sergio, Steinberg, Gregory R, Jones, Russell G, Gallouzi, Imed‐Eddine
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034131/
https://ncbi.nlm.nih.gov/pubmed/29844217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708307
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