The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK agonist AICAR suppresses IFNγ...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Hall, Derek T, Griss, Takla, Ma, Jennifer F, Sanchez, Brenda Janice, Sadek, Jason, Tremblay, Anne Marie K, Mubaid, Souad, Omer, Amr, Ford, Rebecca J, Bedard, Nathalie, Pause, Arnim, Wing, Simon S, Di Marco, Sergio, Steinberg, Gregory R, Jones, Russell G, Gallouzi, Imed‐Eddine
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034131/
https://ncbi.nlm.nih.gov/pubmed/29844217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708307
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