The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK agonist AICAR suppresses IFNγ...

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Bibliografske podrobnosti
izdano v:EMBO Mol Med
Main Authors: Hall, Derek T, Griss, Takla, Ma, Jennifer F, Sanchez, Brenda Janice, Sadek, Jason, Tremblay, Anne Marie K, Mubaid, Souad, Omer, Amr, Ford, Rebecca J, Bedard, Nathalie, Pause, Arnim, Wing, Simon S, Di Marco, Sergio, Steinberg, Gregory R, Jones, Russell G, Gallouzi, Imed‐Eddine
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034131/
https://ncbi.nlm.nih.gov/pubmed/29844217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708307
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