The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK agonist AICAR suppresses IFNγ...

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Библиографические подробности
Опубликовано в: :EMBO Mol Med
Главные авторы: Hall, Derek T, Griss, Takla, Ma, Jennifer F, Sanchez, Brenda Janice, Sadek, Jason, Tremblay, Anne Marie K, Mubaid, Souad, Omer, Amr, Ford, Rebecca J, Bedard, Nathalie, Pause, Arnim, Wing, Simon S, Di Marco, Sergio, Steinberg, Gregory R, Jones, Russell G, Gallouzi, Imed‐Eddine
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034131/
https://ncbi.nlm.nih.gov/pubmed/29844217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708307
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