Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis

5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. Recently, we showed that AICAR-induced AMPK activation inhibits the growth of retinoblastoma cells i...

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Main Authors: Theodoropoulou, Sofia, Brodowska, Katarzyna, Kayama, Maki, Morizane, Yuki, Miller, Joan W., Gragoudas, Evangelos S., Vavvas, Demetrios G.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536763/
https://ncbi.nlm.nih.gov/pubmed/23300996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052852
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