Uveal Melanoma Cell Growth Is Inhibited by Aminoimidazole Carboxamide Ribonucleotide (AICAR) Partially Through Activation of AMP-Dependent Kinase

PURPOSE. To evaluate the effects and mechanism of aminoimidazole carboxamide ribonucleotide (AICAR), an AMP-dependent kinase (AMPK) activator, on the growth of uveal melanoma cell lines. METHODS. Four different cell lines were treated with AICAR (1–4 mM). Cell growth was assessed by 3-(4,5-dimethylt...

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Hauptverfasser: Al-Moujahed, Ahmad, Nicolaou, Fotini, Brodowska, Katarzyna, Papakostas, Thanos D., Marmalidou, Anna, Ksander, Bruce R., Miller, Joan W., Gragoudas, Evangelos, Vavvas, Demetrios G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089421/
https://ncbi.nlm.nih.gov/pubmed/24781943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12856
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