Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo

OBJECTIVES: Iron is an essential element for cell proliferation and growth processes. We have reported that deferasirox (DFX), an oral iron chelator, showed antiproliferative activity against pancreatic cancer cells. This study aimed to elucidate the effects of combination of gemcitabine (GEM), stan...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Shinoda, Shuhei, Kaino, Seiji, Amano, Shogo, Harima, Hirofumi, Matsumoto, Toshihiko, Fujisawa, Koichi, Takami, Taro, Yamamoto, Naoki, Yamasaki, Takahiro, Sakaida, Isao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033369/
https://ncbi.nlm.nih.gov/pubmed/29983871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25421
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