Invasion inhibition in pancreatic cancer using the oral iron chelating agent deferasirox

Abstract Background Iron is required for cellular metabolism, and rapidly proliferating cancer cells require more of this essential nutrient. Therefore, iron regulation may well represent a new avenue for cancer therapy. We have reported, through in vitro and in vivo research involving pancreatic ca...

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Main Authors: Shogo Amano, Seiji Kaino, Shuhei Shinoda, Hirofumi Harima, Toshihiko Matsumoto, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki, Isao Sakaida
Format: Artigo
Jezik:Inglês
Izdano: BMC 2020-07-01
Serija:BMC Cancer
Teme:
Pancreatic cancer
Iron chelation
Cancer therapy
Rho family protein
Deferasirox
Invasion
Online dostop:http://link.springer.com/article/10.1186/s12885-020-07167-8
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