Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in vitro and in vivo

BACKGROUND: Iron is essential for cell replication, metabolism and growth. Because neoplastic cells have high iron requirements due to their rapid proliferation, iron depletion may be a novel therapeutic strategy for cancer. Deferasirox (DFX), a novel oral iron chelator, has been successful in clini...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Harima, Hirofumi, Kaino, Seiji, Takami, Taro, Shinoda, Shuhei, Matsumoto, Toshihiko, Fujisawa, Koichi, Yamamoto, Naoki, Yamasaki, Takahiro, Sakaida, Isao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007806/
https://ncbi.nlm.nih.gov/pubmed/27582255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2744-9
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