Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics

To identify the genetic basis of interindividual variability in montelukast exposure, we determined its pharmacokinetics and sequenced 379 pharmacokinetic genes in 191 healthy volunteers. An intronic single nucleotide variation (SNV), strongly linked with UGT1A3*2, associated with reduced area under...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Hirvensalo, Päivi, Tornio, Aleksi, Neuvonen, Mikko, Tapaninen, Tuija, Paile‐Hyvärinen, Maria, Kärjä, Vesa, Männistö, Ville T., Pihlajamäki, Jussi, Backman, Janne T., Niemi, Mikko
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033076/
https://ncbi.nlm.nih.gov/pubmed/28940478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.891
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