Long-term hypoxia uncouples Ca(2+) and eNOS in bradykinin-mediated pulmonary arterial relaxation

Bradykinin-induced activation of the pulmonary endothelium triggers a rise in intracellular Ca(2+) that activates nitric oxide (NO)-dependent vasorelaxation. Chronic hypoxia is commonly associated with increased pulmonary vascular tone, which can cause pulmonary hypertension in responsive individual...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Regul Integr Comp Physiol
Asıl Yazarlar: Blum-Johnston, Carla, Thorpe, Richard B., Wee, Chelsea, Opsahl, Raechel, Romero, Monica, Murray, Samuel, Brunelle, Alexander, Blood, Quintin, Wilson, Rachael, Blood, Arlin B., Zhang, Lubo, Longo, Lawrence D., Pearce, William J., Wilson, Sean M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032299/
https://ncbi.nlm.nih.gov/pubmed/29513562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00311.2017
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