Long-term hypoxia uncouples Ca(2+) and eNOS in bradykinin-mediated pulmonary arterial relaxation

Bradykinin-induced activation of the pulmonary endothelium triggers a rise in intracellular Ca(2+) that activates nitric oxide (NO)-dependent vasorelaxation. Chronic hypoxia is commonly associated with increased pulmonary vascular tone, which can cause pulmonary hypertension in responsive individual...

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Detalhes bibliográficos
Publicado no:Am J Physiol Regul Integr Comp Physiol
Main Authors: Blum-Johnston, Carla, Thorpe, Richard B., Wee, Chelsea, Opsahl, Raechel, Romero, Monica, Murray, Samuel, Brunelle, Alexander, Blood, Quintin, Wilson, Rachael, Blood, Arlin B., Zhang, Lubo, Longo, Lawrence D., Pearce, William J., Wilson, Sean M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032299/
https://ncbi.nlm.nih.gov/pubmed/29513562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00311.2017
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