Long-term hypoxia uncouples Ca(2+) and eNOS in bradykinin-mediated pulmonary arterial relaxation

Bradykinin-induced activation of the pulmonary endothelium triggers a rise in intracellular Ca(2+) that activates nitric oxide (NO)-dependent vasorelaxation. Chronic hypoxia is commonly associated with increased pulmonary vascular tone, which can cause pulmonary hypertension in responsive individual...

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Dades bibliogràfiques
Publicat a:Am J Physiol Regul Integr Comp Physiol
Autors principals: Blum-Johnston, Carla, Thorpe, Richard B., Wee, Chelsea, Opsahl, Raechel, Romero, Monica, Murray, Samuel, Brunelle, Alexander, Blood, Quintin, Wilson, Rachael, Blood, Arlin B., Zhang, Lubo, Longo, Lawrence D., Pearce, William J., Wilson, Sean M.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032299/
https://ncbi.nlm.nih.gov/pubmed/29513562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00311.2017
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